Evaluation of plasma albumin as a potential prognostic biomarker in patients with traumatic sirs

Abstract

Hypoalbuminemia occurs in about 90% of critically ill patients admitted in the intensive care unit (ICU), this is caused by an increase in microvascular permeability (capillary and venous wall) as a result of systemic inflammatory reaction (SIRS) and decreased synthesis of hepatic albumin in acute liver response. The aim of this study is to determine the incidence of hypoalbuminaemia in patients with non-septic SIRS (induced by surgical trauma or multiple trauma) and to assess the plasma albumin level as a potential biomarker of severity in the prognosis of these patients. The albumin plasma level of ICU admitted patients were determined every 24h and 48h, patients were continuously monitored for complications. Hypoalbuminemia is probably the cause of prolonged ileus, gastroparesis, sepsis, fistula and acute renal failure). The statistical processing of data consisted in compiling descriptive statistics on values of albumin, highlighting the albuminage relationship by the regression method. Calculation of mean plasma albumin values for groups of patients without clinical complications, those with clinical complications or with complications and who died and performing the Scheffe( multiple comparison test), correlation tests between albumin value at 48h and APACHE II score (prediction score Of the critical patient) as well as a descriptive analysis taking into account the 3 g / dl albumin value (factor that differentiates mild to moderate hypoalbuminemia in clinical practice) and performing the non-parametric Chi-Square test for validation of statistical analysis.