The dihydrofolate reductase (DHFR) gene is a target of c-Myc in genomic instability. The induced overexpression of c-Myc in cell lines is followed by the amplification and rearrangement of the DHFR gene. Furthermore, the constitutive upregulation of c-Myc protein coincides with genomic instability of the DHFR gene in lymphoid, non-lymphoid and in tumor lines. The amplification of the DHFR gene is locus-specific and independent of species origins. We have now addressed the question whether inducible deregulation of c-Myc is followed by DHFR gene amplification in vivo. We show that the DHFR gene is a target of c-Myc-dependent neoplasia in vivo and propose a role for genomic instability during the initiation of neoplastic transformation.
CITATION STYLE
Taylor, C., Jalava, A., & Mai, S. (1997). c-Myc dependent initiation of genomic instability during neoplastic transformation. In Current Topics in Microbiology and Immunology (Vol. 224, pp. 201–207). Springer Verlag. https://doi.org/10.1007/978-3-642-60801-8_20
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