The role of a high augmentation index in spontaneous intracerebral hemorrhage to prognosticate mortality

Abstract

The aim of the study was to determine the prognostic value of a high augmentation index, which was a surrogate marker of arterial stiffness in patients with spontaneous intracerebral hemorrhage. The outcome was divided into two groups in which the following data were collected in a computer running SphygmoCor CvMS software version 8.2. Logistic regression analysis was carried out among significant variables to identify an independent predictor of 6-month outcome and mortality. Sixty patients were recruited into the study. Admission Glasgow Coma Scale score (OR, 0.7; 95% CI, 0.450-0.971; P = 0.035), total white cell count (OR, 1.2; 95% CI, 1.028-1.453; P = 0.023) and hematoma volume (OR, 1.1; 95% CI, 1.024-1.204; P = 0.011) were found to be statistically significant for identifying poor 6-month outcome in multivariate analysis. Factors independently associated with mortality were a high augmentation index (OR, 8.6; 95% CI, 1.794-40.940; P = 0.007) and midline shift (OR, 7.5; 95% CI, 1.809-31.004; P = 0.005). Admission Glasgow Coma Scale score, total white cell count and hematoma volume were significant predictors for poor 6-month outcome, and a high augmentation index and midline shift were predictors for 6-month mortality in this study. © 2011 Springer-Verlag/Wien.