While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T cells perform critical, essential functions during immune responses that cannot be compensated by αβ T cells. Accordingly, it is essential to understand how the development of γδ T cells is controlled so that their generation and function might be manipulated in future for therapeutic benefit. This introductory chapter will cover the basic processes that underlie γδ T cell development in the thymus, as well as the current understanding of how they are controlled.
CITATION STYLE
Wiest, D. L. (2015). Development of γδ T cells, the special-force soldiers of the immune system. In T-Cell Development: Methods and Protocols (pp. 23–32). Springer New York. https://doi.org/10.1007/978-1-4939-2809-5_2
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