Abstract
Genetic alterations leading to changes in cell cycle regulation and growth factor signaling transform astrocytes into a tumor phenotype. This chapter describes four grades of astrocytic tumors, discusses how genetic alterations lead to astrocyte transformation, and stresses how growth factor and cell cycle signaling networks contribute to this transformation. Finally we discuss cell lines and animal models pertinent to the study of astrocytic tumors.
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CITATION STYLE
Aeder, S. E., & Hussaini, I. M. (2008). Transformation of Normal Astrocytes Into a Tumor Phenotype. In The Cell Cycle in the Central Nervous System (pp. 433–447). Humana Press. https://doi.org/10.1007/978-1-59745-021-8_30
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