A popular theory in the stem cell field is that 'regeneration recapitulates development', or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle. © The Author (2009). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.
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Wang, J., & Conboy, I. (2010). Embryonic vs. adult myogenesis: Challenging the “regeneration recapitulates development” paradigm. Journal of Molecular Cell Biology, 2(1), 1–4. https://doi.org/10.1093/jmcb/mjp027