Toxicology of synthetic musk compounds in man and animals

Abstract

Synthetic musk compounds (musk fragrances) are chemically heterogeneous compounds. The available toxicological data are incomplete. The NOAEL (No Observed Adverse Effect Level) values, obtained in experimental toxicological studies, are of preliminary nature and can only serve as rough estimates. In the light of the available results and ongoing studies, it therefore seems prudent, in the sense of precautionary principle and consumer protection, to set temporary limits for persistent musk compounds in foodstuffs and cosmetics.