Multiple plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes

59Citations
Citations of this article
179Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Successful invasion of human erythrocytes by Plasmodium falciparum merozoites is required for infection of the host and parasite survival. The early stages of invasion are mediated via merozoite surface proteins that interact with human erythrocytes. The nature of these interactions are currently not well understood, but it is known that merozoite surface protein 1 (MSP1) is critical for successful erythrocyte invasion. Here we show that the peripheral merozoite surface proteins MSP3, MSP6, MSPDBL1, MSPDBL2, and MSP7 bind directly to MSP1, but independently of each other, to form multiple forms of the MSP1 complex on the parasite surface. These complexes have overlapping functions that interact directly with human erythrocytes. We also show that targeting the p83 fragment of MSP1 using inhibitory antibodies inhibits all forms of MSP1 complexes and disrupts parasite growth in vitro.

Cite

CITATION STYLE

APA

Lin, C. S., Uboldi, A. D., Epp, C., Bujard, H., Tsuboi, T., Czabotar, P. E., & Cowman, X. A. F. (2016). Multiple plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes. Journal of Biological Chemistry, 291(14), 7703–7715. https://doi.org/10.1074/jbc.M115.698282

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free