Creutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after a mild COVID-19 infection. He subsequently developed parkinsonism, eventually progressed to akinetic mutism, and passed away 5 months after symptom onset. This case highlights a potential temporal relationship between COVID-19 infection and the onset of neurodegenerative symptoms. Microglia and astrocytes in the central nervous system (CNS) and ‘S1’ spike proteins on SARS-CoV-2 are potential mediators in neuroinflammation and neurodegeneration.
CITATION STYLE
Yong, C. S. K., Maniam, E. J. H., Chang, C. W. L., Lai, J. Y., & Ho, C. S. H. (2023). Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient. Frontiers in Neurology, 14. https://doi.org/10.3389/fneur.2023.1239576
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