Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates

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Abstract

Our purpose was to evaluate the interobserver concordance for the diagnoses of mycosis fungoides (MF), atypical dermatoses (AD), and benign dermatoses (BD) and the impact of T-cell immunophenotyping on the diagnoses MF, AD, and BD. Specimens of MF (n = 57), AD (n = 27), and BD and normal skin (n = 54) were reviewed by 2 hematopathologists and 1 dermatopathologist to establish diagnostic interobserver concordance by routine morphologic examination. Immunophenotyping was performed to evaluate expression of CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, and MIB-1. The interobserver concordance was fair to moderate compared with the original diagnosis. Partial deletion of CD2 alone was associated significantly with MF. Epidermal deletions of 2 or 3 T-cell antigens or 2 T-cell antigens not including CD7 were associated significantly with MF. An elevated CD4/CD8 ratio correlated with MF. Morphologic features were most diagnostic of MF. Immunophenotyping generally resulted in downgrading of the reaction pattern but was helpful in distinguishing MF from benign dermatoses. © American Society for Clinical Pathology.

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APA

Florell, S. R., Cessna, M., Lundell, R. B., Boucher, K. M., Bowen, G. M., Harris, R. M., … Perkins, S. L. (2006). Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates. American Journal of Clinical Pathology, 125(5), 727–736. https://doi.org/10.1309/3JK2H6Y988NUAY37

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