Molecular evidence for a thymus-independent partial T cell development in a FOXN1-/- athymic human fetus

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Abstract

The thymus is the primary organ able to support T cell ontogeny, abrogated in FOXN1-/- human athymia. Although evidence indicates that in animal models T lymphocytes may differentiate at extrathymic sites, whether this process is really thymus-independent has still to be clarified. In an athymic FOXN1-/- fetus, in which we previously described a total blockage of CD4+ and partial blockage of CD8+ cell development, we investigated whether intestine could play a role as extrathymic site of T-lymphopoiesis in humans. We document the presence of few extrathymically developed T lymphocytes and the presence in the intestine of CD3+ and CD8+, but not of CD4+ cells, a few of them exhibiting a CD45RA+ naïve phenotype. The expression of CD3eepTa, RAG1 and RAG2 transcripts in the intestine and TCR gene rearrangement was also documented, thus indicating that in humans the partial T cell ontogeny occurring at extrathymic sites is a thymusand FOXN1-independent process. Copyright: © 2013 Fusco et al.

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Fusco, A., Panico, L., Gorrese, M., Bianchino, G., Barone, M. V., Grieco, V., … Pignata, C. (2013). Molecular evidence for a thymus-independent partial T cell development in a FOXN1-/- athymic human fetus. PLoS ONE, 8(12). https://doi.org/10.1371/journal.pone.0081786

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