Cross-species analysis reveals evolving and conserved features of the nuclear factor κb (NF-κB) proteins

Abstract

Background: NF-κB regulates transcription via binding to DNA and interactions with cofactors. Results: NF-κB binding to DNA and cytosolic IκBs is conserved, whereas binding to nuclear IκBs has evolved. Conclusion: There is distinct evolutionary pressure on two NF-κB/IκB binding interfaces. Significance: The results provide inroads into IκB-specific modulation of NF-κB activity. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.