Cognitive development of singletons conceived by intracytoplasmic sperm injection or in vitro fertilization at age 5 and 10 years

Abstract

Objective To investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years. Methods Sixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children. Results The IQ of the study group fell in the normal range (mean 98.2; SD 12.2). ICSI children (IQ 94.1, SD 13.8) had statistically lower intellectual abilities compared to IVF children (IQ 102.0, SD 9.1; t -2.81, p . 005), especially in simultaneous mental processing. 23.5 ICSI children, but only 2.9 IVF children (p . 011) had at least borderline delayed cognitive development. Conclusions Most artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.