“Inflammaging” refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.
CITATION STYLE
Lu, B., Huang, L., Cao, J., Li, L., Wu, W., Chen, X., & Ding, C. (2021, December 1). Adipose tissue macrophages in aging-associated adipose tissue function. Journal of Physiological Sciences. BioMed Central Ltd. https://doi.org/10.1186/s12576-021-00820-2
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