Regional cerebral blood flow in the rat as determined by particle distribution and by diffusible tracer

Abstract

Measurements of total and regional cerebral blood flow in paralyzed rats maintained on 70 % N20/30 % O2 obtained by a diffusible tracer technique, iodoantipyrine, and by a particle distribution method, microspheres, hare been compared. Total CBF rallies were in good agreement, 0.86 ± 0.07 ml/g/mln (Paco1 37.3 ± 1.5, iodoantipyrine method) and 0.88 ± 0.02 (Paco2 36.2 ± 0.8, mlcrosphere method). Regional cerebral blood flows showed good agreement with the 2 methods, with highest flow in the colliculi, striatum and cerebral cortex and lowest flows in the bypothalamus, pons medulla and cerebellum. The iodoantipyrine method is technically easier to perform and had a higher precision. © 1980 American Heart Association, Inc.