Bupropion extended-release induced spontaneous orgasms

Abstract

Sexual side effects are common with antidepressant use. Spontaneous orgasms have been previously described with several antidepressants. We report the case of a woman who had spontaneous orgasms after starting 300mg/day bupropion extended-release. Spontaneous orgasms ceased 4 days after stopping the bupropion extended-release. Bupropion extended-release is a norepinephrine-dopamine reuptake inhibitor. Norepinephrine- and dopamine-related mechanisms may induce spontaneous orgasms. This unusual side effect should be questioned in patients who receive bupropion, as it may cause embarrassment and noncompliance.