Recent advances have led to several systems to study transcription from defined loci in living cells. It has now become possible to address long-standing questions regarding the interplay between the processes of DNA damage repair and transcription - two disparate processes that can occur on the same stretch of chromatin and which both lead to extensive chromatin change. Here we describe the development of a system to create enzymatically induced DNA double-strand breaks (DSBs) at a site of inducible transcription and methods to study the interplay between these processes. © 2013 Springer Science+Business Media, LLC.
CITATION STYLE
Shanbhag, N. M., & Greenberg, R. A. (2013). The dynamics of DNA damage repair and transcription. Methods in Molecular Biology, 1042, 227–235. https://doi.org/10.1007/978-1-62703-526-2_16
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