Abstract
Small interfering RNA (siRNA) is a promising tool for gene therapy-based disease treatments. However, delivery of siRNA to the target cells requires a specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.
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Kulhari, H., Jangid, A. K., & Adams, D. J. (2019). Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery. In Methods in Molecular Biology (Vol. 1974, pp. 195–201). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9220-1_14
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