A θ-γ oscillation code for neuronal coordination during motor behavior

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Abstract

Sequential motor behavior requires a progression of discrete preparation and execution states. However, the organization of state-dependent activity in neuronal ensembles of motor cortex is poorly understood. Here, we recorded neuronal spiking and local field potential activity from rat motor cortex during reward-motivated movement and observed robust behavioral state-dependent coordination between neuronal spiking, γ oscillations, and θ oscillations. Slow and fast γ oscillations appeared during distinct movement states and entrained neuronal firing. γ oscillations, in turn, were coupled to θ oscillations, and neurons encoding different behavioral states fired at distinct phases of θ in a highly layer-dependent manner. These findings indicate that θ and nested dual band γ oscillations serve as the temporal structure for the selection of a conserved set of functional channels in motor cortical layer activity during animal movement. Furthermore, these results also suggest that cross-frequency couplings between oscillatory neuronal ensemble activities are part of the general coding mechanism in cortex. © 2013 the authors.

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Igarashi, J., Isomura, Y., Arai, K., Harukuni, R., & Fukai, T. (2013). A θ-γ oscillation code for neuronal coordination during motor behavior. Journal of Neuroscience, 33(47), 18515–18530. https://doi.org/10.1523/JNEUROSCI.2126-13.2013

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