During pregnancy, the developing foetus in mothers with Crigler-Najjar type 1 and 2 is exposed to raised levels of unconjugated bilirubin, with the risk of neurotoxicity. We describe two pregnancies in a patient with Crigler-Najjar type 2, who was carefully monitored prior to and during pregnancy and phototherapy adjusted to maintain serum bilirubin levels below 200 μmol/l and the bilirubin/albumin molar ratio below 50%. Both pregnancies resulted in normal delivery of healthy infants who had normal neurological development. A review of all reported pregnancies in Crigler-Najjar patients and a set of recommendations are presented.
CITATION STYLE
Wilson, J. H. P., Sinaasappel, M., Lotgering, F. K., & Langendonk, J. G. (2013). Recommendations for pregnancies in patients with Crigler-Najjar syndrome. In JIMD Reports (Vol. 7, pp. 59–62). Springer. https://doi.org/10.1007/8904_2012_142
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