MIR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer

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Abstract

Understanding the molecular mechanisms underlying gastric cancer progression contributes to the development of novel targeted therapies. In this study, we found that the expression levels of miR-125b were strongly downregulated in gastric cancer and associated with clinical stage and the presence of lymph node metastases. Additionally, miR-125b could independently predict OS and DFS in gastric cancer. We further found that upregulation of miR-125b inhibited the proliferation and metastasis of gastric cancer cells in vitro and in vivo. miR-125b elicits these responses by directly targeting MCL1 (myeloid cell leukemia 1), which results in a marked reduction in MCL1 expression. Transfection of miR-125b sensitizes gastric cancer cells to 5-FU-induced apoptosis. By understanding the function and molecular mechanisms of miR-125b in gastric cancer, we may learn that miR-125b has the therapeutic potential to suppress gastric cancer progression and increase drug sensitivity to gastric cancer.

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Wu, S., Liu, F., Xie, L., Peng, Y., Lv, X., Zhu, Y., … He, X. (2015). MIR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. BioMed Research International, 2015. https://doi.org/10.1155/2015/365273

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