Development and In-Vitro Evaluation of Itraconazole Loaded Nanoemulsion

Abstract

Nanoemulsions are one of the major popular formulation systems in the pharmaceutical and cosmeceutical fields. Nanoemulsions are generally composed of a dispersed oil phase within a continuous aqueous phase. Itraconazole is an antifungal medication used to treat a number of fungal infections. It is in the triazole family of medications. Itraconazole, antifungal agent has poor bioavailability due to low aqueos solubility.  In this research preformulation study, Fourier transform infrared (FTIR) analysis studies was conducted for studying the compatibility. In preparation of Itraconazole loaded nanoemulsions from the ternary phase diagram ratio of surfactant to co-surfactant (Smix) was optimized with broad area. Optimized surfactant and co surfactant are accurately weighed and then vortexed for 5-10 min for Smix preparation. Particle size and value of PDI was found to be 159.21nm and zeta potential demonstrated the stability of prepared nanoparticles was found to be -15.9mv .Transmission electron microscope indicated a homogeneous distribution of small, spherical optimized Itraconazole loaded nanoemulsion formulation. These studies were aimed to improve the oral bioavailability of Itraconazole through nanoemulsions. Keywords: Nanoemulsion, Itraconazole, Surfactant, cosurfactant, Nanoparticles