Stimulation of NF-κB activation and gene expression by platelet- activating factor

Abstract

PAF stimulation of NF-κB activation and transcription of immediate- early genes have been investigated in peripheral blood mononuclear cells and in transfected Chinese hamster ovary cells expressing the cloned PAF receptor. These studies identified a G protein-coupled pathway for PAF induction of gene expression and transcription factor activation, which differs from the mechanisms employed by other immediate-early gene inducers. Potential significance of PAF induced NF-κB activation is discussed.