Endurance testing simultaneously assesses a wide variety of physiological systems including the cardiovascular, respiratory, metabolic, and neuromuscular systems (Gabriel and Zierath, Cell Metab 25:1000–1011, 2017). Treadmill running is a noninvasive method to evaluate fitness capacity in a longitudinal or cross-sectional manner. High-intensity exercise tests can be used to determine peak physical capacity in mice. However, because aging is associated with a progressive loss of physical capacity the running protocols can be adapted and optimized for aged mice.
CITATION STYLE
Reynolds, J. C., & Lee, C. (2020). Mouse Fitness as Determined Through Treadmill Running and Walking. In Methods in Molecular Biology (Vol. 2144, pp. 57–65). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0592-9_5
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