Cardiovascular magnetic resonance in Marfan syndrome

Abstract

The cardiovascular features and complications of Marfan syndrome (MFS) consist of a spectrum of valvular, myocardial and great vessel pathologies, which require screening and lifelong serial surveillance. Ninety-five percent of deaths in MFS are related to cardiovascular manifestations, with aortic dissection accounting for the most common cause of cardiovascular related mortality [1–3]. Cardiovascular complications are less readily detectable at the early stages compared to ocular and skeletal manifestations, as patients are typically asymptomatic. This brings into focus the relevance of early diagnosis and timely intervention to prevent potentially catastrophic adverse outcomes including death.