The LabelHash server and tools for substructure-based functional annotation

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Abstract

Summary: The LabelHash server and tools are designed for large-scale substructure comparison. The main use is to predict the function of unknown proteins. Given a set of (putative) functional residues, LabelHash finds all occurrences of matching substructures in the entire Protein Data Bank, along with a statistical significance estimate and known functional annotations for each match. The results can be downloaded for further analysis in any molecular viewer. For Chimera, there is a plugin to facilitate this process. © The Author 2011. Published by Oxford University Press. All rights reserved.

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Moll, M., Bryant, D. H., & Kavraki, L. E. (2011). The LabelHash server and tools for substructure-based functional annotation. Bioinformatics, 27(15), 2161–2162. https://doi.org/10.1093/bioinformatics/btr343

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