This chapter focuses on the use of retinoids in the chemoprevention of keratinocyte carcinomas (KC) and will aim to demystify their use in the clinical arena by offering a practical approach to optimize clinical benefits and minimize adverse effects. The last decade has ushered in a handful of agents with demonstrated efficacy in the prevention of KC including vismodegib, sirolimus, DNA repair enzymes, cyclooxygenase-2 (COX-2) inhibitors, and capecitabine which will be discussed. Topical imiquimod, 5-fluoruracil (5-FU), and photodynamic therapy have been detailed elsewhere (see Chaps. 2 and 4). Vismodegib is covered in detail in Chap. 22.
CITATION STYLE
Lucero, O. M., Zwald, F. O. R., & Lambert, D. (2021). Chemoprevention of Keratinocyte Carcinomas. In Skin Cancer Management: A Practical Approach (pp. 335–351). Springer International Publishing. https://doi.org/10.1007/978-3-030-50593-6_21
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