Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

Abstract

Aging is a complex and progressive process characterized byphysiological and functional decline with time that increasessusceptibility to diseases. Aged-related functional change isaccompanied by a low-grade, unresolved chronic inflammationas a major underlying mechanism. In order to explain aging inthe context of chronic inflammation, a new integrative concepton age-related chronic inflammation is necessary thatencompasses much broader and wider characteristics of cells,tissues, organs, systems, and interactions between immuneand non-immune cells, metabolic and non-metabolic organs.We have previously proposed a novel concept of senescent(seno)-inflammation and provided its frameworks. This reviewsummarizes senoinflammation concept and additionallyelaborates modulation of senoinflammation by calorierestriction (CR). Based on aging and CR studies andsystems-biological analysis of Omics big data, we observedthat senescence associated secretory phenotype (SASP)primarily composed of cytokines and chemokines was notablyupregulated during aging whereas CR suppressed them. Thisresult further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence ofsenoinflammation and modulatory role of CR provide insightsinto aging mechanism and potential interventions, therebypromoting healthy longevity.