Studies on 2-Oxoquinoline Derivatives as Blood Platelet Aggregation Inhibitors. II. 6-[3-(1-CyclohexyI-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and Related Compounds

Abstract

A series of ω-(l-substituted-5-tetrazolylalkoxy)-2-oxoquinolines was synthesized and tested for inhibitory activity towards collagen- and adenosine diphosphate (ADP)-induced aggregation of rabbit blood platelets in vitro. These compounds were prepared by the reaction of l-substituted-5-(ω-chloroalkyl)-tetrazoles and hydroxy-2-oxoquinolines in the presence of a base. Among them, 6-[3-(l-cyclohexyl-5-tetrazolyl)propoxy]-l,2-dihydro-2-oxoquinoline (IVb) was found to have the most potent inhibitory activity. The structure-activity relationships are discussed. © 1983, The Pharmaceutical Society of Japan. All rights reserved.