Targeting Heat Shock Proteins in Multiple Myeloma

Abstract

The heat shock proteins (Hsp), the family of molecular chaperons, are key proteins in protein folding and maturation. The client proteins of Hsp are critical in number of biological processes including cellular proliferation, differentiation , survival, metastasis, invasion, and angiogenesis. Thus, Hsp family becomes one of the desirable targets for cancer treatment. It has been demonstrated that Hsp overexpress in multiple myeloma and linked in poor prognosis and relapse. This chapter describes about the Hsp and their possible link with the pathogenesis of multiple myeloma. It addresses the advancement and challenges in the development of Hsp inhibitors.