Objective: This study assessed the relationship between the parameters of glycemic control, and zinc concentrations in blood and superoxide dismutase enzyme activity in type 2 diabetes patients. Subjects and methods: Seventy-three individuals, aged between 25 and 59 years, were divided into the experimental group (type 2 diabetes patients, n = 36) and control group (n = 37). Plasma and erythrocyte zinc concentrations, superoxide dismutase activity, and parameters of glycemic control were analyzed. Results: Mean plasma zinc concentration was 74.1 ± 10.7 μg/dL and 68.8 ± 9.6 μg/dL, erythrocyte zinc concentration was 48.1 ± 9.5 μg/gHb and 41.2 ± 8.0 μg/gHb, and superoxide dismutase activity was 2248.9 ± 300.0 U/gHb and 2059.6 ± 285.4 U/gHb, in the experimental group and the control group, respectively (p < 0.05). Conclusion: Type 2 diabetes patients showed a positive response to oxidative stress due to adequate zinc concentration in blood and increased activity of superoxide dismutase, and the enzyme was infuenced by serum insulin.
CITATION STYLE
de Sousa Lima, V. B., de Araújo Sampaio, F., Bezerra, D. L. C., Neto, J. M. M., & Marreiro, D. do N. (2011). Parameters of glycemic control and their relationship with zinc concentrations in blood and with superoxide dismutase enzyme activity in type 2 diabetes patients. Arquivos Brasileiros de Endocrinologia e Metabologia, 55(9), 701–707. https://doi.org/10.1590/s0004-27302011000900006
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