Infectious mononucleosis

Abstract

Infectious mononucleosis (IM) was first described in 1889 as glandular fever, a clinical illness characterized by fever, fatigue, abdominal discomfort, hepatosplenomegaly (enlargement of both the liver and spleen), and lymphadenopathy. Later.observations linking the appearance of atypical lymphocytosis helped.to establish IM as a clinical entity. It was not until 1968 that IM was linked to the Epsteln-Barr virus (EBV). EBV Is one of the most ubiquitous human herpes viruses, and it is associated with more than 90% of cases of IM.