Enantioselective allylic substitutions in natural product synthesis

Abstract

Enantioselective transition metal-cataylzed allylic substitution reactions constitute a broad and deep methodology that has expanded to incorporate ever more metals and ligands. The utility of these processes is reflected in the wide range of natural product and drug target total syntheses that incorporate asymmetric allylic alkylations as the key step or steps. © 2011 Springer-Verlag Berlin Heidelberg.