Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function (Review)

Abstract

Circular RNA (circRNA ) molecules are noncoding RNA s with unique circular covalently closed structures that contribute to gene expression regulation, protein translation and act as microRNA sponges. circRNA s also have important roles in human disease, particularly tumorigenesis and antitumor processes. Methylation is an epigenetic modification that regulates the expression and roles of DNA and coding RNA and their interactions, as well as of noncoding RNA molecules. Previous studies have focused on the effects of methylation modification on circRNA expression, transport, stability, translation and degradation of circRNA s, as well as how circRNA methylation occurs and the influence of circRNAs on methylation modification processes. circRNA and methylation can also regulate disease pathogenesis via these interactions. In the present study, we define the relationship between circRNA s and methylation, as well as the functions and mechanisms of their interactions during disease progression..