Tyrosine kinase medications and the skin

Abstract

In recent years, numerous targeted therapy medications have been developed and utilized for the treatment of solid and hematologic malignancies. While these medications often demonstrate better Anti-Tumor efficacy than conventional chemotherapeutics, they frequently lead to a range of nonimmunologic cutaneous adverse effects. Skin reactions associated with tyrosine kinase inhibitors include inflammatory eruptions such as acneiform folliculitis and hand foot skin reaction, and new onset of benign and malignant neoplasms. Tyrosine kinase medications and their associated skin reactions will be reviewed here.