Helper-dependent adenoviral vectors (HDAd) are deleted of all viral coding sequences and have demonstrated tremendous potential for gene therapy by providing long-term, high-level transgene expression in the absence of chronic toxicity. Thus, HDAd are superior to early generation Ad for gene therapy of genetic diseases where long-term transgene expression is required. This chapter describes in detail the rescue, amplification, and large-scale production of HDAd. © 2008 Humana Press, Totowa, NJ.
CITATION STYLE
Palmer, D. J., & Ng, P. (2008). Methods for the production of helper-dependent adenoviral vectors. Methods in Molecular Biology, 433, 33–53. https://doi.org/10.1007/978-1-59745-237-3_3
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