Transcriptional regulation of apoptosis

Abstract

Apoptosis is tightly regulated at the transcriptional level through a number of transcription factors. In response to different stimuli, these transcription factors bind to specific DNA sequences in the promoters of the genes that are involved in apoptosis regulation to stimulate or suppress their expression, leading to apoptosis initiation. Transcriptional regulation of apoptosis is essential for tissue homeostasis and normal development and serves as a barrier against tumorigenesis.