Galectin-3 in cardiovascular disease

Abstract

Galectin-3 (Gal-3) is a member of the β-galactoside binding protein family. It is discussed as a novel plasma biomarker secreted mainly by macrophages and different tissues like lung, ovary, breast and others. Gal-3 is probably not expressed in significant amounts in the myocardium. Recombinant mouse models are available. Gal-3 might be a drug target which is increased in the plasma in heart failure and kidney disease. In the experimental setting Gal-3 is associated with fibrosis development. High plasma Gal-3 concentrations were found to be associated with cardiovascular mortality in different studies. However, absolut plasma values differ considerably.