Synthesis and Medicinal Importance of Benzoxazine, Benzoxazinone and Their Derivatives: A Short Review

Abstract

The research in the pharmacology and medicine is in various ways related with synthesis of medicinally important new compounds. The structural basic skeleton of many drugs and compounds with biological activity contains heterocyclic ring with oxygen, nitrogen and sulphur. Benzoxazin, benzoxazinone and many other compounds having these skeleton are heterocyclic and are of great medicinal importance. The synthesis of benzoxazine, benzoxazinone and their derivatives has been able to draw attention of researchers due to their various medicinal uses and physiological activities. Chemically benzoxazine is a heterocyclic compound. It has an oxazine ring fused with a benzene ring. Oxazine ring is a six membered heterocyclic ring with oxygen and nitrogen atom. Benzoxazine and benzoxazinone are reported to exhibit many useful pharmacological properties including anti-inflammatory, analgesic, antifungal, neuroprotective, and antibacterial activities etc. This review is an attempt to throw some light on synthesis and biological activities of benzoxazines, benzoxazinones and their derivatives. This review motivates researchers to synthesize newer benzoxazine derivatives that can be found to be better drug than already available with lesser toxicity.