Retrolental fibroplasia

Abstract

During the past five years 56 cases of retrolental fibroplasia have occurred among premature babies in two units in Manchester. A survey of 629 infants has shown that only three cases occurred before 1950. The early stages of the disease are outlined. Phases suggestive of venous obstruction are illustrated. Support is given to the term 'retinopathy of prematurity'. On six occasions the early changes of the disease have been noted to regress rapidly upon replacing the infant in high tensions of oxygen. Variations in the method of administration of oxygen appear to be closely linked with the incidence of retrolental fibroplasia. It is suggested that retrolental fibroplasia can develop when the tension of oxygen available to the tissues of the premature infant is suddenly lowered.