Antinociceptive and anti-inflammatory effects of ethanol extract from vernonia polyanthes leaves in rodents

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Abstract

The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

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Temponi, V. D. S., Da Silva, J. B., Alves, M. S., Ribeiro, A., de Pinho, J. de J. R. G., Yamamoto, C. H., … de Sousa, O. V. (2012). Antinociceptive and anti-inflammatory effects of ethanol extract from vernonia polyanthes leaves in rodents. International Journal of Molecular Sciences, 13(3), 3887–3899. https://doi.org/10.3390/ijms13033887

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