Dna-binding and antimicrobial studies of molybdenum complexes

Abstract

Molybdenum complexes were synthesized and characterized for their purity by various physico-chemical methods like IR, Electronic, NMR Spectral studies. The interaction of complex with calf Thymus DNA (CT-DNA) was studied by using absorption, emission, Spectral methods, thermal denaturation and vis- cometry studies. The results suggest that the Mo(V) complex intercalates into DNA base pairs via the dithiophosphamate ligand Antimicrobial activity of complexes against certain microbial species has been carried out by serial dilution method to evaluate the MIC (Minimum inhibitory concentration) value. Results showed that Metal complexes are most active as compared to ligand fragments.