In a prospective study of 101 mother-child pairs in Jamaica, we examined the association of provirus load in breast milk and the risk of mother-to-child transmission of human T lymphotropic virus type I. The provirus load in breast milk was a strong predictor of risk of transmission to children (relative risk, 2.34/quartile), after adjustment for other known risk factors. The risk of transmission increased from 4.7/1000 person-months when the provirus load in breast milk was <0.18% to 28.7/1000 person-months when it was >1.5%. Provirus detection in maternal breast milk predicted transmission months before infection in children was detected by serologic testing.
CITATION STYLE
Li, H. C., Biggar, R. J., Miley, W. J., Maloney, E. M., Cranston, B., Hanchard, B., & Hisada, M. (2004). Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I. Journal of Infectious Diseases, 190(7), 1275–1278. https://doi.org/10.1086/423941
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