Cryo-Electron Tomography: The Resolution Revolution and a Surge of in Situ Virological Discoveries

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Abstract

The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-ET resolution revolution. Meanwhile, significant efforts have been made to improve the identification of targets in the cellular context and the throughput of cryo-focused ion beam (FIB) milling. Together, these developments led to a surge of in situ discoveries on how enveloped viruses are assembled and how viruses interact with cells in infected hosts. In this article, we review the recent advances in cryo-ET, high-resolution insights into virus assembly, and the findings from inside infected eukaryotic and prokaryotic cells.

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Hong, Y., Song, Y., Zhang, Z., & Li, S. (2023, May 9). Cryo-Electron Tomography: The Resolution Revolution and a Surge of in Situ Virological Discoveries. Annual Review of Biophysics. Annual Reviews Inc. https://doi.org/10.1146/annurev-biophys-092022-100958

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