Genetic tools available for the mouse make it a powerful model to study the modulation of cochlear function by descending control systems. Suppression of distortion product otoacoustic emission (DPOAE) amplitude by contralateral acoustic stimulation (CAS) provides a robust tool for noninvasively monitoring the strength of descending modulation, yet investigations in mice have been performed infrequently and only under anesthesia, a condition likely to reduce olivocochlear activation. Here, we characterize the contralateral olivocochlear reflex in the alert, unanesthetized mouse. Head-fixed mice were restrained between two closed acoustic systems, while an artifact rejection protocol minimized contamination from self-generated sounds and movements. In mice anesthetized with pentobarbital, ketamine or urethane, CAS at 80 dB SPL evoked, on average, a
CITATION STYLE
Chambers, A. R., Hancock, K. E., Maison, S. F., Liberman, M. C., & Polley, D. B. (2012). Sound-evoked olivocochlear activation in unanesthetized mice. JARO - Journal of the Association for Research in Otolaryngology, 13(2), 209–217. https://doi.org/10.1007/s10162-011-0306-z
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