Sound-evoked olivocochlear activation in unanesthetized mice

52Citations
Citations of this article
76Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Genetic tools available for the mouse make it a powerful model to study the modulation of cochlear function by descending control systems. Suppression of distortion product otoacoustic emission (DPOAE) amplitude by contralateral acoustic stimulation (CAS) provides a robust tool for noninvasively monitoring the strength of descending modulation, yet investigations in mice have been performed infrequently and only under anesthesia, a condition likely to reduce olivocochlear activation. Here, we characterize the contralateral olivocochlear reflex in the alert, unanesthetized mouse. Head-fixed mice were restrained between two closed acoustic systems, while an artifact rejection protocol minimized contamination from self-generated sounds and movements. In mice anesthetized with pentobarbital, ketamine or urethane, CAS at 80 dB SPL evoked, on average, a

Cite

CITATION STYLE

APA

Chambers, A. R., Hancock, K. E., Maison, S. F., Liberman, M. C., & Polley, D. B. (2012). Sound-evoked olivocochlear activation in unanesthetized mice. JARO - Journal of the Association for Research in Otolaryngology, 13(2), 209–217. https://doi.org/10.1007/s10162-011-0306-z

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free