The Effects of New Cytochalasins from Phomopsis sp: And the Derivatives on Cellular Structure and Actin Polymerization

Abstract

The effects of ten 10-phenyl-[ll]cytochalasans produced by Phomopsis sp. including novel compounds having 5,7-or 6,7-glycol structures and their derivatives, on the cell morphology and actin distribution in C3H-2K cells, as well as on lymphocyte capping and actin polymerization, were examined. The structure-activity relationship reported in the previous papers has been confirmed. The novel glycol type compounds showed little or no activity, suggesting the importance of the perhydroisoindol-l-one nucleus for the manifestation of the cytochalasin actions. © 1990, The Pharmaceutical Society of Japan. All rights reserved.