Efficient and environmentally benign synthetic protocol for the synthesis of structurally diverse annulated pyridopyrimidines

Abstract

Structurally diverse annulated pyridopyrimidines have been synthesized by an efficient and environmentally benign synthetic protocol involving catalyzed four-component reaction of 2-aminobenzothiazoles with thiophene-2-carbaldehyde and carbonyl compounds in ethanol. Mild reaction conditions, operational simplicity, and structural diversity with excellent yields are some special attractions of the present protocol. © 2014 The Author(s). Published by Taylor & Francis.