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The complexation of 2,4-dinitrophenol with basic drugs: Acid + base = salt

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Abstract

Different drugs containing a basic nitrogen atom were crystallised with 2,4-dinitrophenol to study the mode of complexation in search of an antidote to 2,4-dinitrophenol poisoning. The protonated forms of quininium, quinidinium and trazodonium form N–H···O hydrogen bonds to the deprotonated O atom of the 2,4-dinitrophenolate anion, whereas haloperidolium forms a bifurcated N–H···(O,O) hydrogen bond to the deprotonated O atom of 2,4-dinitrophenol and an O atom of the adjacent nitro group. Hydrogen-bonded chains occur in the quininium, quinidinium and haloperidolium crystal structures, whereas the trazodonium structure consists of ion pairs. These results are discussed with a view to lowering the toxicity of 2,4-dinitrophenol in the body in the case of an overdose.

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APA

Plater, M. J., & Harrison, W. T. A. (2019). The complexation of 2,4-dinitrophenol with basic drugs: Acid + base = salt. Journal of Chemical Research, 48(7–8), 281–286. https://doi.org/10.1177/1747519819861079

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