Protein folding landscapes and protein-protein interaction landscapes are subject to modulation by many factors inside living cells: crowding, electrostatics, hydrophobic interactions, and even hydrodynamic phenomena. The resulting spatiotemporal fluctuations in protein folding rates, protein stability, protein structure, protein function, and protein interactions are the subject of a recent generation of experiments, as well as in-cell modeling. We discuss some specific examples of how the cell modulates energy landscapes and leads to fluctuations that may, in some cases, simply be a consequence of statistical physics, but, in other cases, may be exploited by the cell to improve its fitness.
CITATION STYLE
Guo, M., & Gruebele, M. (2016). Spatiotemporal fluctuations of protein folding in living cells. In Molecular Science of Fluctuations Toward Biological Functions (pp. 205–219). Springer Japan. https://doi.org/10.1007/978-4-431-55840-8_10
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