Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO2 (concentration range studied: 40-1,000 p.p.m.) increases death rates due to H2O2 stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H2O 2-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx -dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO2 concentration. Thus, CO2 exacerbates ROS toxicity by increasing oxidative cellular lesions. © 2011 European Molecular Biology Organization.
CITATION STYLE
Ezraty, B., Chabalier, M., Ducret, A., Maisonneuve, E., & Dukan, S. (2011). CO2 exacerbates oxygen toxicity. EMBO Reports, 12(4), 321–326. https://doi.org/10.1038/embor.2011.7
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